The species is known to be sensitive to the effects of antibiotics. Unless there are facilities available for close observation and monitoring of blood pressure, linezolid should not be administered to patients with the following underlying clinical conditions or on the following types of concomitant medications: - Patients with uncontrolled hypertension, phaeochromocytoma, carcinoid, thyrotoxicosis, bipolar depression, schizoaffective disorder, acute confusional states. However, the difference in clearance is small and is not reflected in the apparent elimination half-life. Linezolid should only be initiated in a hospital environment and after consultation with a relevant specialist such as a microbiologist or infectious diseases specialist. The aminoethoxyacetic acid metabolite (PNU-142300) is less abundant. Approximately 30% of a linezolid dose is removed during 3 hours of haemodialysis, but no data are available for the removal of linezolid by peritoneal dialysis or haemoperfusion. The compatibility and stability studies were conducted of linezolid in parenteral nutrition mixtures of basic, high- and low-electrolytic, high- and low-energetic and immunomodulatory composition. Shorter treatment regimens may be suitable for some types of infection but have not been evaluated in clinical trials. Therefore, linezolid is not recommended for use in these circumstances unless close observation and monitoring of the recipient is possible (see sections 4.3 and 4.5). This suggests that it is only necessary to avoid ingesting excessive amounts of food and beverages with a high tyramine content (e.g. Those most commonly reported were diarrhoea (8.4 %), headache (6.5%), nausea (6.3%) and vomiting (4.0%). Store in the original package (overwrap and carton) until ready to use in order to protect from light. Hypersensitivity to linezolid or to any of the excipients listed in section 6.1. In rats, slight maternal toxicity was noted at exposures lower than clinical exposures. If linezolid is to be given concomitantly with other drugs, each drug should be given separately in accordance with its own directions for use. In compassionate use studies, a higher incidence of serious anaemia was reported in patients receiving linezolid for more than the maximum recommended duration of 28 days. Whereas linezolid shows some in vitro activity against Legionella, Chlamydia pneumoniae and Mycoplasma pneumoniae, there are insufficient data to demonstrate clinical efficacy. Peripheral neuropathy, as well as optic neuropathy and optic neuritis sometimes progressing to loss of vision, have been reported in patients treated with Linezolid; these reports have primarily been in patients treated for longer than the maximum recommended duration of 28 days. Therefore, it is important to consider this diagnosis in patients who present with diarrhoea subsequent to the administration of any antibacterial agent. For streptococci (including S. pneumoniae) the breakpoints are Susceptible ≤ 2 mg/L and Resistant >4 mg/L. Carcinogenicity/oncogenicity studies have not been conducted in view of the short duration of dosing and lack of genotoxicity. To date, there is no experience of linezolid administration to patients undergoing continuous ambulatory peritoneal dialysis (CAPD) or alternative treatments for renal failure (other than haemodialysis). Studies in animals have shown reproductive toxicity (see section 5.3). However, the following information may prove useful: Supportive care is advised together with maintenance of glomerular filtration. Specifically, it binds to a site on the bacterial ribosome (23S of the 50S subunit) and prevents the formation of a functional 70S initiation complex which is an essential component of the translation process. Linezolid is an oxazolidinone-type antibacterial agent which inhibits bacterial protein synthesis by specifically binding to the 50S ribosomal subunit. During clinical use of linezolid with serotonergic agents, including antidepressants such as selective serotonin reuptake inhibitors (SSRIs), cases of serotonin syndrome have been reported. In patients with MRSA pneumonia compli- Linezolid is the only licensed member of the new group of synthetic antimicrobials within the class oxazolidinones that have activity against most Gram-positive bacteria and mycobacteria. 1 ml solution for infusion contains 2 mg linezolid. Linezolid is indicated in adults for the treatment of community acquired pneumonia and nosocomial pneumonia when known or suspected to be caused by susceptible Gram-positive bacteria. The mechanism of this interaction and its clinical significance are unknown. The in vitro postantibiotic effect (PAE) of linezolid for Staphylococcus aureus was approximately 2 hours. Increased sodium or calcium. Check the expiry date on the bottle and do not use it after this date. In normotensive healthy volunteers, linezolid enhanced the increases in blood pressure caused by pseudoephedrine and phenylpropanolamine hydrochloride. Linezolid solution for infusion is compatible with the following solutions: • Glucose 5% (50 mg/ml) Solution for Infusion. There are very limited data from drug interaction studies and on the safety of linezolid when administered to patients with underlying conditions and/or on concomitant medications which might put them at risk from MAO inhibition. Similarly, linezolid does not induce P450 isoenzymes in rats. No special requirements for disposal. Hepatic impairment: Limited data indicate that the pharmacokinetics of linezolid, PNU-142300 and PNU-142586 are not altered in patients with mild to moderate hepatic insufficiency (i.e. Increased or decreased chloride. When warfarin was added to linezolid therapy at steady-state, there was a 10% reduction in mean maximum INR on co-administration with a 5% reduction in AUC INR. Linezolid should not be used during pregnancy unless clearly necessary i.e. Additionally, it is chemically incompatible with ceftriaxone sodium. Linezolid reversibly decreased fertility and induced abnormal sperm morphology in adult male rats at exposure levels approximately equal to those expected in humans; possible effects of linezolid on the human male reproductive system are not known (see section 5.3). In rats, slight maternal toxicity was noted at exposures lower than expected clinical exposures. Continue, 2. In cases where the outcome is known, when linezolid was discontinued, the affected haematologic parameters have risen toward pretreatment levels. Absorption is not significantly affected by food and absorption from the oral suspension is similar to that achieved with the film-coated tablets. Controlled clinical trials did not include patients with diabetic foot lesions, decubitus or ischaemic lesions, severe burns or gangrene. Plasma linezolid Cmax and Cmin (mean and [SD]) at steady-state following twice daily intravenous dosing of 600 mg have been determined to be 15.1 [2.5] mg/l and 3.68 [2.68] mg/l, respectively. If your dose is different, do not change it unless your doctor tells you to do so. The elimination half-life of linezolid averages at about 5-7 hours. : localised abdominal pain, transient ischaemic attacks and hypertension solution also contains 0.38 mg i.e. Non-Renal clearance at higher linezolid concentrations or B ( e.g the solution infusion. 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