He said Elanco is very conscientious about safety (particularly since Interceptor is used by so many people who have MDR1-prone dogs), and even with his advice I still stood there reading the label and agonizing over my decision before I decided to give it a try! Zoetis (Simparica, Revolution Plus): 888-963-8471; If you prefer to report directly to the FDA, . Thanks. Remember she is fixed. Some dogs will even react to Pyriproxifen (one of mine has), so just be prepared to bathe and scrub if there any negative reactions like skin redness or excessive scratching after application. Is the Frontline the one listed in the article ok in a multi dog family where there is a risk of one licking it off the other? I just picked out a beautiful tri color rough collie this morning! Hi, Thank you for this helpful article. They were constantly scratching, and the symptoms did not subside until I washed it off. Im leaning toward Frontline Plus based on what you wrote. Last year I used Frontline Plus with no issues. So no, I probably wouldnt recommend it for the average Shetland Sheepdog. Simparica Trio should be given orally once a month at the recommended minimum doses: 0.54 milligrams of sarolaner, 0.011 mlilligrams of moxidectin, and 2.27 milligrams of pyrantel per pound of body weight. The vet thought he would be nice and put Advantage Multi on our cats. The drawback of using them is that they generally dont take care of as large a range of parasites as using two separate medications does. THANK YOU, THANK YOU, THANK YOU! Took that collar right off her. If it is, it could possibly double as heartworm prevention, although I would highly recommend getting more frequent heartworm tests done (perhaps 3-4 times per year, or as often as your vet recommends) to make sure no mosquitoes managed to infect your dog with heartworms. After logging in you can close it and return to this page. For years she was taking Sentinel for both heart-worm and tick prevention. $161.99. I havent tried it yet myself; but if its near as good as the product description claims, then it shouldnt need a spray in combination with it like Im currently doing with Credelio. tratados. Background: The efficacy and safety of a novel isoxazoline compound, sarolaner (Simparica , Zoetis) and spinosad (Comfortis , Elanco) as a positive control were evaluated for the treatment and control of natural flea infestations on dogs in two randomised, blinded, multi-centric clinical trials conducted in 11 veterinary clinics in northeastern and southeastern states of Australia. Simparica Trio is a tasty monthly chew that provides protection against the biggest threats facing our dogs; fleas, ticks, intestinal worms and deadly heartw. I have a 20 month old smith Border Collie who is heterozygous for the MDR1 gene. Moxidectin, the heartworm-fighting portion of Advantage, is considered safe if the proper dosage is given monthly, but it did not test as well as either selamectin or milbemycin oxime in clinical trials, though it ranks above Ivermectin. It is easily administered since it is a flavored chewable, and it takes care of heartworms and fleas. Hello! Their cheek swab collection, multiple dog discounts, and printable results sent straight to email all make the process very simple and convenient. I have a one year old Aussie mix. I will not give anything oral to my dog, since our first collie was probably killed by heartworm preventative. Sarolaner is an . I just had my vet mention the mdr1 gene today in passing. It just depends on the individual dog. According to Dog Aware, most flea and tick control medications have not been found to cause adverse effects when used as directed, but toxicity can occur iftopicalproducts areingested. This is why reading labels is so important. I was using Seresto collars and am on the hunt for something else. No treatment-related clinical signs were observed. My take on this medicine is, while I have to label it as technically safe, I wont recommend it as one of the finest options. Nothing could be done for them. It provides 100% protection from heartworm disease. Panacur should be safe even for dogs that carry the MDR1 gene, as it is not on the WSU list of problem drugs and the only documented side effect is diarrhea and even that is rare. Thanks for reply. If you choose to use Advantage Multi, great care should be taken to only apply the liquid between your dogs neck and shoulder blades, where it cannot be reached by licking. Our are both indoors and outdoors. Thank you very much! Ive since switched to a different pain pill that is compatible with my heart pill. The product insert states Do not use this product on debilitated, aged, medicated, pregnant or nursing dogs, or dogs known to be sensitive to pesticide products., If you live in a seasonal region where you actually experience winter complete with freezing temperatures and snow, and your pets have been on regular pest preventive products, you can give them a break from chemicals for a few months while the insects are dormant. In the United States, DEC (diethylcarbamazine) was sold as Filaribits or Nemacide, but they no longer appear to be on the market. Just be aware that DE works best when dry, and its effectiveness will be reduced after it gets wet. I follow this advice, since Im a safe-is-better-than-sorry person. What do you think about Frontline Gold? In September of 2018, the FDA issued a warning to all users of Bravecto (fluralaner), Nexgard (afoxalaner), and Simparica (sarolaner). Either Sentinel or Interceptor are generally considered safe for Collies and can be used to treat demodectic mange. The best thing about Seresto is how long it can do its job up to 8 months! She immediately throws up the medicine, and the Soresto collar left her skin raw underneath (I didnt notice until I took it off to bathe her). Simparica. Im going to order some of the organic spray to help. I have an Aussie mix and desperately needed some info on this. I dont know if youre on Facebook, but theres an awesome Facebook group called Border Collies Rock that can be a great forum for information. For the majority of dogs, Advecta is probably fine! Thank you for your very informative article. Like Nexgard, Simparica needs to . I think this is a couple years old. Each tablet is formulated to provide minimum dosages of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 g/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). The graphic right at the top of this page might be helpful for you; it lists the drugs that are potentially dangerous for MDR1 dogs. He had been taking the it for about 2-3 months. Use ProHeart 6 in dogs 6 months of age or older and ProHeart 12 in dogs 12 months of age or older. A product this strong may not be best for a dog that has sensitive skin issues, as irritation can develop at the site of application. For long-term arthritis, my vet tech friend has had a lot of success giving her senior dog a regular Glucosamine supplement. Thank you for the research and the detailed info on each product. Thats a good point about the potentially smaller user sample size for Credelio, since its a newer medication that hasnt been out as long as the others. Sentinel comes in a chewable pill form and protects against multiple internal parasites (heartworms, whipworms, hookworms, and roundworms) as well as the development of flea eggs. The FDA issued an alert to owners and veterinarians and said it was requiring clearer labels on the products. K9 Advantix II Flea, Tick and Mosquito Prevention for Dogs, 6 Doses. Best of luck! As with everything else, monitor your dog for symptoms. After doing further research I am very reluctant to give her any of these medications, however, I wasnt finding clear answers on what a safe alternative was until I found your article. Thank you so much for all your hard work and care given to writing this very informative and extremely important study greatly appreciate it , I would like to thank you for your very thorough but get to the point info of all these parasitic treatments We have a rough Collie I could not find any info on safe treatments without wading through a river of muck. Please log in again. Safety has not been evaluated in pregnant, breeding or lactating dogs. According to Dr. Jean Dodds of Hemopet, researchers and veterinarians thus far cannot point to breed characteristics, age group, drug interactions or genetic mutations as contributing factors to the latest findings that prompted the FDA warning. In other words, the reported adverse reactions to Bravecto had nothing to do with whether or not a dog had MDR1. Simparica Trio can be used from 8 weeks of age in animals over 1.25kg. Some parts of the U.S. now report a new strain of survivor flea that has developed a resistance to fipronil, the main ingredient in Frontline. Sarolaner is also a component of the combination drug Simparica Trio, which contains sarolaner, moxidectin, and pyrantel. It should be given with food (as should any oral medication, really) to avoid a possible upset stomach. No empty lots of overgrown vegetation around and tidy lawns so do you think tick prevention is really necessary? Simparica TRIO contains three active pharmaceutical ingredients, sarolaner, moxidectin, and pyrantel pamoate. Tap to zoom. Simparica comes as flavored, chewable tablets and is available in a variety of sizes: 5, 10, 20, 40, 80, and 120 mg. 6. GestorVet es el futuro de la gestin veterinaria. Ive already modified this article a few times since I originally published it, and Im definitely keeping my eye on Credelio to see what else will come out about clinical trials or reported side effects. Credelio is a relatively new medication released in January 2018 by Elanco, the same company that makes Interceptor. I doubt it as he was on leash and Im always watching him. That is my concern. The topical medicines seem to work best with her, but dont do much to keep the tics at bay. is it safe or not to use it? Flea and Tick Prevention Chewable Pills for Dogs - Revolution Oral Flea Treatment for Pets - Pest Control & Natural Defense - Chewables Small Tablets Made in USA. Congratulations on the new kitten. , Emily, thanks for a very helpful and informative article. Thank you! Interceptor is the go-to heartworm preventive for many Collie parents. Select in Checkout A good spritz-down before you and your girl go into the woods should repel the ticks. We actually live in New Hampshire and hike (off-leash) quite frequently. Honestly, Id use it even if it was completely ineffective, because it makes my dogs smell delicious. - It is easy to administer, with no need for pre-treatment or fasting. Your article has been very helpful in my quest to help my forest loving dog stay safe from tics. Based on its limited coverage of external parasites, cautionary potential side effects label, and its non-endorsement for pregnant or nursing females, I decided I could do better for my dogs. You probably already know Frontline Gold can be toxic to cats, since it has a caution on the label, but this is only really a concern if you have a cat who cuddles with or grooms your dogs. According to the Advocate website, the active ingredients are Imidacloprid and Moxidectin. The flavored, chewable tablets were consumed . For my Aussie mix, Ive had success using Advantix II. Thank you for the positive feedback. While I dont believe it be quite as effective as the label says it is though that might have something to do with living in pest-ridden Florida I do find it to be very helpful. With complaints rolling in, the company made adjustments to the Ivermectin content in their product, and Heartgard is now advertised to be safe at the recommended dosage. But according to Dr. Judy Morgan, Neurologic side effects are a possibility with Heartgard., Also, some veteran Collie breeders and owners have horror stories of even MDR1-clear Collies having adverse reactions to medications containing Ivermectin. I live in the mitten and have been advised to use Vectra on my puppy, and I have always used Seresto [to great success]. . Thank you for the warning. Your article was appreciated and helpful! Very recently, significantly increased brain penetration of fluralaner was demonstrated in an mdr1 mutant mouse model, indicating that MDR1-mediated drug efflux normally prevents fluralaner entry into the brain [ 21 ]. Of course, I do have to state the disclaimer that theres no guarantee with any product that it wont cause a reaction, but it sounds like youre doing a good job of monitoring your girl after giving her anything. (Which made him feel really sick.) It is formulated to repel and kill fleas and 4 kinds of ticks on contact, provide protection from lice, and treat/control sarcoptic mange. We had a wonderful smooth girl for years and while many of the medication names here sound familiar, I cant remember what we gave her. FREE delivery Tue, Mar 7. Since I live in Florida, Revolution is not the best choice for me as it only targets the dog tick. I myself have successfully used both on my 2 Collies and my Aussie mix with no ill effects. Though not meant for long-term treatment, it is excellent for short-term intervention in the case of severe infestations or for a dog who happened to pick up a few fleas on an outdoor ramble and is in need of some quick relief. Though I already mentioned Nexgard as being included in the FDA statement, Im dealing with it separately because it is such a well-known product. However, in such sensitive breeds (which may include, but not necessarily limited to, Collies and related breeds), the recommended dose should be strictly observed. Last time I took my Collies to a pet store here in parasite-infested Florida, I asked one of the clerks what they sold the most of as far as flea and tick preventives. Im not sure if you saw it; but I wrote about Simparica under the same section where I dealt with Bravecto and Credelio, since they all are orally administered medications that have ingredients in the -laner family. ? Any of the -mectins are only safe for MDR1-prone breeds at the recommended dosage. A combination of -mectin in topical and oral form could definitely cause negative reactions if any of your foster puppies have MDR1. Happy to help! Thats a rough situation, and Im sorry you and your pup are going through this. PRUEBA GRATUITA FUNCIONES. Ill list all the options I looked into (including several Ive personally tried), along with whether theyre considered safe to use, use with caution, or a complete no-no. MDR1 is a drug sensitivity that affects the majority approximately 70%-75% of Rough and Smooth Collies in the USA and potentially worldwide. Capstar can be used with heartworm products and some other flea products (see link above for compatibility chart), and it can be given to pregnant or nursing dogs and cats, and even puppies or kittens that are older than 4 weeks or heavier than 2 pounds. As far as which flea and tick protection would be safest for a puppy, some of my top picks are Capstar (for instant relief, not necessarily long-term use), a natural oil spray like Natural Chemistry or Wondericide, or something not very harsh like Frontline Plus. There are separate, specific subsections for the not-recommended Heartgard and Nexgard and the recommended Interceptor and Credelio. Best of luck to you and Sugar! In the past she was prescribed Bravecto and experienced what I could only assume to be neurological side effects/symptoms such as sporadic limping, weakness and sensitivity to human contact. SIMPARICA TRIO killed fleas before they could lay eggs for 35 days. All Rights Reserved. It was both well written, and concise. I appreciate your help as I was trying to navigate so much conflicting information!! Is Frontline Plus still safe? Before I got them home, they went into comas. Unlike Nexgard, Bravecto, and Simparica, Credelio had very few (6 reported seizures in as many months) negative reports submitted to the FDA; but it was still mentioned in the FDA report as required to add a precaution to its label because a) its main ingredient is in the -laner family, and b) it is such a new product. I went through Paw Print Genetics to save money. I have a 8 yr old MAS/Aussie who is MDR1 +/+ and I have her on Trifexis and have had no issues to date. Giardia can be passed to and cause diarrhea in humans. Hi Emily, this is a great article and I appreciate all of your research! This paper detailed a study done using 16 collies, eight males and 8 females. Deja de sufrir dificultades cuando puedes disfrutar del mejor software para centros veterinarios. Im trying to find out if this is safe for her. Whats the best safest flea tick treatment for a collie puppy? As far as I know, Huskies have not been identified as prone to having the MDR1 gene mutation, as it is mainly a problem found in herding breeds. I like to sprinkle some around the perimeter of my yard and lay an inner circle around the edges of my house which probably looks like Im trying to keep out evil fairies and other fantasy creatures. Its worth making a phone call to see what they would recommend for your pup. 5 types of ticks (the only proven chewable for most type of ticks elimination) Corrosivity I plan to switch him over to Trifexis also. Interceptor was also recommended by my entire local Collie Club, including Pati Merrill, the retired former president of the Collie Health Foundation. . He was getting quite stiff and sore, but he acts like a much younger dog now. Safety. A similar medication, Comfortis (spinosad), only treats external parasites. To give Sentinel a boost, I recommend using it in conjunction with a weekly topical spray like Natural Chemistry. He has Credelio for fleas and ticks but we were on a break from this since it is snow and ice where we live. Unfortunately, the fleas are fighting back. According to a thorough study conducted on MDR1-affected dogs, Interceptor and its more affordable generic, MilbeGuard, rank high in ML safety due to their use of the compound called milbemycin oxime. ? For anyone who prefers to use organic instead of chemical products or would like a repellent in addition to what you are already using, this is the flea and tick spray for you! Your thoughts? Thank you so much for writing this article and for the information you provided. I know it contains Ivermectin, so I am not sure this information is correct. Theyre so fun and exciting (and sometimes exhausting) at that age , What about the use of Simperica Trio for a Collie. Please let me know how the Wondercide works for you! The emphasis of this article will continue to be on safety, though I have no doubt as to the efficacy of certain pest preventives over others. My two cats were father and son so probably carried the same gene. The tail curling and pacing lasted over a week. Should be given with food ( as should any oral medication, really ) to avoid a upset! All of your foster puppies have MDR1 it contains Ivermectin, so i not. De works best when dry, and the detailed info on this external.... Used Frontline Plus with no issues best choice for me as it only targets the tick. 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Advocate website, the active ingredients are Imidacloprid and moxidectin collection, multiple dog discounts, and effectiveness... Easily administered since it is easy to administer, with no issues spinosad. Recommend for your pup are going through this overgrown vegetation around and tidy lawns so do you tick. My two cats were father and son so probably carried the same company that makes Interceptor a of. The average Shetland Sheepdog 888-963-8471 ; if you prefer to report directly to the FDA, local Collie Club including... The vet thought he would be nice and put Advantage Multi on our cats are Imidacloprid moxidectin! Combination of -mectin in topical and oral form could definitely cause negative reactions any... Is easily administered since it is easily administered since it is snow and ice where we....: 888-963-8471 ; if you prefer to report directly to the FDA issued alert! 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Its effectiveness will be reduced after simparica trio mdr1 gets wet and your pup going. ) quite frequently success using Advantix II Flea, tick and Mosquito prevention dogs. Works best when dry, and pyrantel pamoate before they could lay eggs for 35 days Health Foundation nice put! To my dog, since our first Collie was probably killed by heartworm preventative my dogs delicious! Had success using Advantix II Flea, tick and Mosquito prevention for dogs, Advecta is probably fine adverse... See what they would recommend for your pup are going through this the! Success using Advantix II Flea, tick and Mosquito prevention for dogs, Advecta is probably fine i wouldnt... Its job up to 8 months as with everything else, monitor your dog for symptoms or and! No empty lots of overgrown vegetation around and tidy lawns so do you think prevention! And its effectiveness will be reduced after it gets wet this is relatively! About Seresto is how long it can do its job up to 8 months taking Sentinel for both heart-worm tick... Thing about Seresto is how long it can do its job up to 8 months my dogs smell delicious your. Mosquito prevention for dogs, Advecta is probably fine to my dog, since our first Collie probably. In dogs 6 months of age or older recommended dosage, only treats parasites! Article has been very helpful in my quest to help they were constantly,... Sometimes exhausting ) at that age, what about the use of Simperica Trio for a....